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SIRT3, Active

Recombinant human SIRT3 (47-end) was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Catalog No. S37-38G


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Catalog No. Pack Size Price (USD)
S37-38G-05 5 ug $259
S37-38G-10 10 ug $380
S37-38G-BULK BULK Contact Us  


Overview:

SIRT3 is a member of the class I of the Sirtuin family that is characterized by a Sirtuin core domain. Sirtuin are grouped into four classes and are homologs to the Sir2 protein. SIRT3 is known to regulate the epigenetic gene silencing and suppresses recombination of rDNA (1). SIRT3 may function as an intracellular regulatory protein with mono-ADP-ribosyltransferase activity that is essential for its silencing function. SIRT3 regulates and maintains basal ATP levels in the cell (2). SIRT3 also modulates mitochondrial intermediary metabolism and fatty acid use during fasting (3).


Gene Aliases:

SIR2L3, Sirtuin 3


Genbank Number:


References:


1. Tanny, J. C. et.al: An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99: 735-745, 1999.

2. Ahn, B.-H. et.al: A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Nat. Acad. Sci. 105: 14447-14452, 2008.

3. Hirschey, M. D. et.al: SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464: 121-125, 2010.


Specific Activity:

Sample SIRT Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~66 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  SIRT1, Active, S35-31H

  SIRT5, Active, S39-30H

  SIRT2 Protein, S36-30EG

  SIRT3 Protein, S37-30EG


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