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SIRT5, Active

Recombinant full length human SIRT5 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. S39-30H


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Catalog No. Pack Size Price (USD)
S39-30H-05 5 ug $259
S39-30H-10 10 ug $380
S39-30H-BULK BULK Contact Us  


Overview:

SIRT5 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT5 being a member of class III. SIRT5 consists of eight exons and is found in two isoforms which encode a 310 aa and a 299 aa protein, respectively. Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. Fluorescence in situ hybridization analysis localized the human SIRT5 gene to chromosome 6p23. SIRT5 can deacetylate cytochrome c, a protein of the mitochondrial intermembrane space with a central function in oxidative metabolism as well as apoptosis initiation (1).


Gene Aliases:

SIR2L5, Sirtuin 5


Genbank Number:


References:


1. Schlicker C. et al: Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol. 2008 Oct 10;382(3):790-801.

2. Mahlknecht, U. et al: Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. Cytogenet Genome Res. 2006;112(3-4):208-12.


Specific Activity:

Sample SIRT Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~39 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


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  SIRT1, Active, S35-31H

  SIRT6 Protein, S40-30EG

  Acetylated Histone H4 Peptide I, H13-358


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