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HDAC8, Active

Full-length recombinant human HDAC8 was expressed by baculovirus in Sf9 insect cells using a C-terminal His tag.
Catalog No. H90-30H


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Catalog No. Pack Size Price (USD)
H90-30H-05 5 ug $226
H90-30H-10 10 ug $325
H90-30H-BULK BULK Contact Us  


Overview:

HDAC8 or Histone deacetylase 8 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. The protein encoded by this gene belongs to class I of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors (1). There are 2 adjacent histidine residues in the predicted active site (His142 and His143) that are required for HDAC activity on H4 peptide substrates and core histones (2). The knockdown of HDAC8 by RNA interference inhibited the growth of human lung, colon, and cervical cancer cell lines.


Gene Aliases:

HDACL1; RPD3


Genbank Number:


References:


1. Buggy, J. J. et.al: Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem. J. 350: 199-205, 2000.

2. Vannini, A. et.al: Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. Proc. Nat. Acad. Sci. 101: 15064-15069, 2004.


Specific Activity:

Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~47 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  HDAC9, Active, H91-31G

  HDAC4, Active, H86-31G

  Acetylated Histone H3 Peptide I, H12-358

  HDAC8, Active, H90-30G


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