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HDAC5, Active

Recombinant mouse HDAC5 (617-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H87-31G


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Catalog No. Pack Size Price (USD)
H87-31G-05 5 ug $226
H87-31G-10 10 ug $325
H87-31G-BULK BULK Contact Us  


Overview:

HDAC5 or Histone deacetylase 5 belongs to the class II histone deacetylase/acuc/apha family that possesses histone deacetylase activity and represses transcription when tethered to a promoter (1). HDAC 5 plays a critical role in transcriptional regulation, cell cycle progression, and developmental events and also acts as a potential therapeutic target for the prevention of atherosclerosis. HDAC5 can co-immunoprecipitates with HDAC3 family members forming multicomplex proteins. HDAC5 can also interact with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. HDAC5 gene is thought to be associated with colon cancer (2).


Gene Aliases:

mHDA1; AI426555; mKIAA0600


Genbank Number:


References:


1. Grozinger, C. M. et.al : Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Nat. Acad. Sci. 96: 4868-4873, 1999.

2. Scanlan, M. J. et.al: Characterization of human colon cancer antigens recognized by autologous antibodies. Int. J. Cancer 76: 652-658, 1998.


Specific Activity:

Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~80 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


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