Home   >    Enzymes   >   Epigenetic Enzymes

HDAC3, Active

Full-length recombinant human HDAC3 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Catalog No. H85-30G


Shop Online



Catalog No. Pack Size Price (USD)
H85-30G-05 5 ug $226
H85-30G-10 10 ug $325
H85-30G-BULK BULK Contact Us  


Overview:

HDAC3 or Histone deacetylase 3 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC3 may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. Catalytic domain of HDAC4 can interact with HDAC3 via the transcriptional corepressor NCOR2 (1). RELA is a nonhistone substrate of HDAC3 and IKBA-dependent nuclear export of the HDAC3-deacetylated RELA replenishes the depleted cytoplasmic pool of latent NFKB-IKBA complexes (2).


Gene Aliases:

HD3; RPD3; RPD3-2


Genbank Number:


References:


1. Chen, L. et. al: Duration of nuclear NF-kappa-B action regulated by reversible acetylation. Science 293: 1653-1657, 2001.

2. Fischle, W. et al: Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Molec. Cell 9: 45-57, 2002.


Specific Activity:

Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~83 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  HDAC2, Active, H84-30G

  HDAC7, Active, H89-31G

  Anti-Acetylated Lysine, HRP Conjugated, L95-66DR

  Acetylated Histone H3 Peptide I, H12-358


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox