HDAC1 or Histone deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex which plays a key role in the regulation of eukaryotic gene expression (1). HDAC1 interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis. HDAC1 is an essential element of the co-activation system for IFN-induced gene regulation and antiviral responses (2).
HD1, RPD3, GON-10, RPD3L1, DKFZp686H12203
1. Bauer, W. R. et.al : Nucleosome structural changes due to acetylation. J. Molec. Biol. 236: 685-690, 1994.
2. Nusinzon, I. et.al : Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Nat. Acad. Sci. 100: 14742-14747, 2003.
Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
MB Robers et al., Target engagement and drug residence time can be observed in living cells with BRET Nature Communications December 2015 10.1038/ncomms10091
Jaskula-Sztul Renata et al., Tumor suppressor role of Notch3 in Medullary Thyroid Carcinoma revealed by genetic and pharmacological induction Molecular Cancer Therapeutics November 2014 10.1158/1535-7163.MCT-14-0073
Hou Xuben et al., Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8 Journal of Chemical Information and Modeling March 2015 10.1021/ci500762z
S Jang et al., Novel analogs targeting histone deacetylase suppress aggressive thyroid cancer cell growth and induce re-differentiation. Cancer Gene Therapy August 2015 10.1038/cgt.2015.37
Cancer, Cell Cycle, Inflammation