Overview:

EPHA8 is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family in ahich EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats (1). EPHA8 receptors play a role in axonal pathfinding during development of the mammalian nervous system (2).

Gene Aliases:

EEK, HEK3, KIAA1459

Genbank Number:

NM_020526

References:

1. Chan, J., et.al: Eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. Oncogene 6: 1057-1061, 1991.

2. Park, S. et.al: Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. EMBO J. 16: 3106-3114, 1997.