Specificity:

Recognizes the PTK7 protein

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

PTK7 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human PTK7

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of PTK7 in (A) human colon, (B) mouse kidney and (C) rat liver tissue lysate with PTK7 antibody at 1 ug/mL.

Sample Data:

Immunohistochemistry of PTK7 in human colon tissue with PTK7 antibody at 2.5 ug/mL.

References :

1. Park SK et al: Characterization of the human full-length PTK7 cDNA encoding a receptor protein kinase-like molecule closely related to chick KLG. J. Biochem.1996; 119:235-9.

2. Lu X et al: PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature2004; 430:93-8.

3. Easty DJ et al: Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. Int. J. Cancer1997; 1061-5.

4. Muller-Tidow C et al: High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clin. Cancer Res.2004; 10:1241-9.