Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
P283-63R-100	100 ug	$595
P283-63R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

P283-63R-100

100 ug

$595

P283-63R-BULK

BULK

References:

1. Shuai K et al: Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

2. Nelson V et al: A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-,ediated transactivation but not apoptosis. Apoptosis2001; 6:221-34.

3. Nishida T et al: PIASy controls ubiquitin-dependent proteasomal degradation of Ets-1. Biochem. J.2007; 405:481-8.

4. Galanty Y et al: Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature2009; 462:935-9.

Specificity:

Recognizes the PIAS4 protein

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

PIAS4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human PIAS4

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of PIAS4 in rat brain tissue lysate with PIAS4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.