Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
P281-63R-100	100 ug	$595
P281-63R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

P281-63R-100

100 ug

$595

P281-63R-BULK

BULK

References:

1. Shuai K et al: Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

2. Arora T et al: PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J. Biol. Chem.2003; 278:21327-30.

3. Patel JH et al: BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. J. Biol. Chem.2007; 282:5-13.

4. Saito M et al: BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA2009; 106:11294-9.

Specificity:

Recognizes the PIAS2 protein

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

PIAS1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human PIAS1

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of PIAS2 in rat brain tissue lysate with PIAS2 antibody at (A) 1 and (B) 2 ug/mL.