Anti-PHLPP1
Rabbit Polyclonal Antibody
Catalog No. P71-263R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P71-263R-100 | 100 ug | $595 | |
| P71-263R-BULK | BULK | Contact Us |
Rabbit Polyclonal Antibody
Catalog No. P71-263R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P71-263R-100 | 100 ug | $595 | |
| P71-263R-BULK | BULK | Contact Us |
References:
1. Brognard J al: PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol. Metab. 2008; 19:223-30.
2. Gao T al: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 2005; 18:13-24.
3. Brognard J al: PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol. Cell 2007; 25:917-31
4. Andreozzi F al: Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. Diabetologia 2011; 54:1879-87.
Specificity:
Recognizes the PHLPP1 protein
Cross Reactivity:
Human
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
PHLPP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human PHLPP1
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Western blot analysis of PHLPP1 in SW480 cell lysate with PHLPP1 antibody at (A) 1 and (B) 2 ug/mL.
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There are no related publications available for this product.
AKT/PKB Pathway, Cancer, Phosphatases, PKA/PKC Pathway
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