Rabbit Polyclonal Antibody
Catalog No. P07-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P07-63R-100 | 100 ug | $595 | |
P07-63R-BULK | BULK | Contact Us |
Overview:
PAK7 (also known as PAK5) is a novel human PAK family kinase that contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus (1). The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the cytoskeleton and apoptosis. PAK7 like the other Paks has been implicated in the regulation of cell morphology, motility and transformation.
References:
1. Pandey, A. et al: Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene. 2002 May 30;21(24):3939-48.
Specificity:
Recognizes the PAK7 protein
Cross Reactivity:
Human
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
PAK7 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK7
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Western blot analysis of PAK7 in T24 lysate with PAK7 antibody at (A) 2 and (B) 4 ug/ml.
Sample Data:
Immunocytochemistry of PAK7 in K562 cells with PAK7 antibody at 2 ug/ml.
There are no related publications available for this product.
Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
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