Rabbit Polyclonal Antibody
Catalog No. U231-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
U231-63R-100 | 100 ug | $595 | |
U231-63R-BULK | BULK | Contact Us |
Overview:
UBE2N (UBC13) or ubiquitin-conjugating enzyme E2N is a member of the E2 ubiquitin-conjugating enzyme family which plays a role in DNA post-replication repair. UBE2N gene encodes a novel human E2 that may be involved in protein degradation in the muscles and testis (1). UBE2N plays a role in initiation of homologous recombination during double-strand break repair (2). UBE2N activity may have therapeutic uses in controlling inflammatory responses and it is also important in the induction of immune responses.
References:
1. Yamaguchi, T. et.al: Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. J. Biochem. 120: 494-497, 1996.
2. Zhao, G. Y. et.al: A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Molec. Cell 25: 663-675, 2007.
Specificity:
Recognizes the UBE2N (UBC13) protein
Cross Reactivity:
Human, Mouse and Rat
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
UBE2N (UBC13) antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UBE2N (UBC13).
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Western blot analysis of UBE2N in human small intestine cell lysates with UBE2N antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Sample Data:
Immunohistochemistry of UBE2N in mouse thymus tissue with UBE2N antibody at 2 ug/ml.
There are no related publications available for this product.
Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Neurobiology
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