Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
T57-363R-100	100 ug	$595
T57-363R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

T57-363R-100

100 ug

$595

T57-363R-BULK

BULK

Overview:

TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily (1). TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-kB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation (2).

References:

1. Wajant, H. Et al: The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 2001; 13 (6): 389–400.

2. Bradley, J.R., Pober, J.S. Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene, 2001; 20 (44): 6482–9.

Specificity:

Recognizes the TRAF2 protein

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

TRAF2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TRAF2

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of TRAF2 in mouse liver tissue lysate with TRAF2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.