Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
S51-63BR-100	100 ug	$595
S51-63BR-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

S51-63BR-100

100 ug

$595

S51-63BR-BULK

BULK

Overview:

STK39 (also known as serine threonine kinase 39) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress (1). STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure (2).

References:

1. Johnston, A. M. et.al: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene 19: 4290-4297, 2000.

2. Chen LY. et.al: STK39 is an independent risk factor for male hypertension in Han Chinese. Int J Cardiol, 2010 Oct 1.

Specificity:

Recognizes the STK39 (STLK3) protein

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

STK39 antibody was raised against a 18 amino acid synthetic peptide from near the center of human STK39

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of STK39 in rat brain tissue lysate with STK39 antibody at (A) 1 and (B) 2 ug/ml.