Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
I11-63R-100	100 ug	$595
I11-63R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

I11-63R-100

100 ug

$595

I11-63R-BULK

BULK

Overview:

IRAK3 or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which is essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling (1). IRAKM mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis (2). Mutations in IRAK3 are associated with a susceptibility to asthma.

References:

1. Del Fresno, C. et.al: Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4. J. Immun. 174: 3032-3040, 2005.

2. Deng, J. C. et.al: Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116: 2532-2542, 2006.

Specificity:

Recognizes the IRAK3 protein and has no cross response to IRAK or IRAK2

Cross Reactivity:

Human, Mouse and Rat

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

IRAK3 antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK3

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of IRAK3 in mouse spleen (M) and rat liver (R) tissue lysates with IRAK3 antibody at 1 ug/ml.