Rabbit Polyclonal Antibody
Catalog No. S34-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S34-63R-100 | 100 ug | $595 | |
S34-63R-BULK | BULK | Contact Us |
Overview:
DRAK2 is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis (1). DRAK2 is selectively important for T-cell survival and inhibition of DRAK2 has therapeutic potential for autoimmune disease (2). T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals and deficiency of DRAK2 can affect autoimmune disease susceptibility without generalized suppression of the immune system (3).
References:
1. Sanjo, H. et.al: DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J. Biol. Chem. 273: 29066-29071, 1998.
2. Ramos, S. J. et.al: Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity. J. Immun. 181: 7606-7616, 2008.
3. McGargill, M. A. et.al: Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J. Immun. 181: 7593-7605, 2008.
Specificity:
Recognizes the DRAK2 (STK17B) protein and has no cross responses to DAP or ZIP kinases.
Cross Reactivity:
Human
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
DRAK2 (STK17B) antibody was raised against a peptide corresponding to amino acids 351 to 365 of human DRAK2 (STK17B)
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Western blot analysis of DRAK2 (STK17B) in Jurkat (1,3) and Raji (2,4) cell lysate in the absence (1,2) or presence (3,4) of blocking peptide with DRAK2 (STK17B) antibody at 1:500 dilution.
Sample Data:
Immunocytochemistry of DRAK2 (STK17B) in Jurkat cells with DRAK2 (STK17B) antibody at 10 ug/ml.
Jie Gao Ling et al., Discovery of Dual Death-Associated Protein Related Apoptosis Inducing Protein Kinase 1 and 2 Inhibitors by a Scaffold Hopping Approach Journal of Medicinal Chemistry September 2014 10.1021/jm5007929
ME Jung et al., Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening. Bioorganic & Medicinal Chemistry Letters June 2016 10.1016/j.bmcl.2016.03.111
Piotr Leonczak Dr et al., Synthesis and Structure-Activity Relationship Studies of 2-(1, 3, 4-Oxadiazole-2 (3H)-thione)-3-amino-5-arylthieno [2, 3-b] pyridines as Inhibitors of DRAK2 ChemMedChem November 2014 10.1002/cmdc.201402234
Apoptosis/Autophagy, Metabolic Disorder, Ser/Thr Kinases
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