Rabbit Polyclonal Antibody
Catalog No. F17-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
F17-63R-100 | 100 ug | $245 | |
F17-63R-BULK | BULK | Contact Us |
Overview:
The mammalian target of rapamycin, mTOR, also known as FRAP or RAFT, is a Ser/Thr protein kinase. mTOR acts as a sensor for ATP and amino acids, balancing the availability of nutrients and cell growth (1). When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal, transmits a positive signal to p70 S6 kinase and participates in the inactivation of the eIF4E inhibitor, 4E-BP1 (2).
References:
1. Sabers CJ et al: Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 270(2): 815-22, 1995.
2. Fang Y. et al: Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science. 294(5548): 1942-5, 2001.
Specificity:
Recognizes the mTOR protein
Cross Reactivity:
Western blot of mTOR from human cells
mTOR from other species may also be detectable.
Host:
Rabbit
Immunogen:
Synthetic peptide corresponding to amino acids 2446-2450 of human mTOR
Purification:
Affinity chromatography
Stability:
Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Representative western blot with Anti-mTOR (1:1000) using 3 μg, 10 μg, and 30 μg of HeLa cell lysate.
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder
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