Overview:

p47ING3 is a tumor suppressor protein similar to ING1 that  can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Over-expression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) that encodes the longest isoform

References:

1. Nagashima,M., et al.: A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Oncogene. 2003: 22 (3); 343-350.

2. Gunduz,M., et al.: Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Oncogene. 2002: 21 (28; 4462-4470.

3. He, G.H., et al.: Phylogenetic Analysis of the ING Family of PHD Finger Proteins. Mol Biol Evol. 2005: 22(1); 104-116.