Overview:

Anti-Cyclin-E antibody detects cyclin-E. Cyclin E is a member of the cyclin family. Cyclin E binds to the G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle that determines cell division. The Cyclin E/CDK2 complex phosphorylates p27Kip1, tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase. Anti-cyclin-e Antibody is ideal for investigators involved in Cell Signaling, cell biology and Signal Transduction research.

References:

1. Koff, A., et al.: Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell. 1991: 66; 1217-1228.

2. Koff, A., et al.: Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science. 1992: 257; 1689-1694.

3. Claudio, P.P., et al.: Functional analysis of pRb/p130 intereaction with cyclins. Cancer Res. 1996: 56; 2003-2008.