Overview:

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product forms a complex with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.

References:

1. Giordano, A., et al.: A 60 kd cdc-2 associated polypeptide complexes with the E1A proteins of adenovirus-infected cells. Cell. 1989: 58; 981-990.

2. Pines, J., et al.: Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature. 1990: 346; 760-763.