Overview:

Cdc27 (a.k.a. cell division cycle protein 27, CDC27Hs and H-NUC) is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits. APC catalyzes the formation of cyclin B-ubiquitin conjugate that controls the ubiquitin-mediated proteolysis of B-type cyclins. Cdc27 contains a TPR (tetratricopeptide repeat) domain, which facilitates protein-protein interactions. This protein interacts with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, pointing to a role in mitotic timing.

References:

1. Topper,L.M., et al. The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. Cell Cycle. 2002:1 (4); 282-292.

2. Wassmann,K., et al.: Mad2 transiently associates with an APC/p55Cdc complex during mitosis. Proc. Natl. Acad. Sci. U.S.A. 1988: 95 (19); 11193-11198.