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FES, Active

Recombinant full-length human FES was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. F03-10G


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Catalog No. Pack Size Price (USD)
F03-10G-05 5 ug $226
F03-10G-10 10 ug $325
F03-10G-BULK BULK Contact Us  


Overview:

FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins (1). FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity (2). FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex.


Gene Alisases:

FPS


Genbank Number:


References:


1. Smithgall T E. et al: The c-Fes family of protein-tyrosine kinases. Crit Rev Oncog. 1998;9(1):43-62.

2. Greer, P.: Closing in on the biological functions of Fps/Fes and Fer. Nat Rev Mol Cell Biol. 2002 Apr;3(4):278-89.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~125kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases, Inflammation


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