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DNMT3B, Active

Recombinant full-length human DNMT3B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D353-380BG


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Catalog No. Pack Size Price (USD)
D353-380BG-05 5 ug $259
D353-380BG-10 10 ug $380
D353-380BG-BULK BULK Contact Us  


Overview:

DNMT3B or DNA (cytosine-5-)-methyltransferase 3 beta encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. DNMT3B can methylate unmethylated and hemimethylated DNA with equal efficiencies (1). DNMT3B localizes primarily to the nucleus and its expression is developmentally regulated and is required for genome wide de novo methylation and is essential for mammalian development (2). Mutations in DNMT3B casue the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.


Gene Aliases:

ICF; ICF1; M.HsaIIIB


Genbank Number:


References:


1. Yanagisawa, Y. et al: The human DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents. Biochim. Biophys. Acta 1577: 457-465, 2002.

2. Okano, M. et al: DNA methyltransferase Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257, 1999.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~138 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology


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  TRDMT1 (DNMT2) Protein, T352-30G


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