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DNMT3A, Active

Recombinant full-length human DNMT3A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D353-380G


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Catalog No. Pack Size Price (USD)
D353-380G-05 5 ug $259
D353-380G-10 10 ug $380
D353-380G-BULK BULK Contact Us  


Overview:

DNMT3A: DNA (cytosine-5-)-methyltransferase 3 alpha plays important role in genomic imprinting and X chromosome inactivation and is essential for mammalian development. DNMT3A appears to function as a de novo methyltrabsferase, since it can methylate unmethylated and hemimethylated DNA with equal efficiencies (1). DNMT3A is required for genome wide de novo methylation and is essential for mammalian development (2). DNMT3A is critical for maintaining active chromatin states of genes that are essential for development.


Gene Aliases:

DNMT3A2; M.HsaIIIA


Genbank Number:


References:


1. Yanagisawa, Y. et al: The human DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents. Biochim. Biophys. Acta 1577: 457-465, 2002.

2. Okano, M. et al: DNA methyltransferase Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257, 1999.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~162 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology


RELATED PRODUCTS


  DNMT Substrate-1, D53-58

  DNMT3B, Active, D353-380BG

  DNMT3L, Active, D353-380CG

  DNMT1 Protein, D351-31G


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