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SETD7, Active

Recombinant full-length human SETD7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S344-380G


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Catalog No. Pack Size Price (USD)
S344-380G-05 5 ug $259
S344-380G-10 10 ug $380
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Overview:

SETD7 or SET domain containing lysine methyltransferase 7 is a lysine methyltransferase which can methylates lysine-4 (K4) in histone H3 in vitro and in vivo. Methylation of K4 in histone H3 by SETD7 and methylation of K9 in histone H3 by SUV39H1 were found to have differential effects on subsequent histone acetylation by p300 (1). SETD7 can also methylate p53 at lys372 within the C-terminal regulatory region (2). Methylated p53 is restricted to the nucleus and the modification positively affects its stability. SETD7 regulates the expression of p53 target genes in a manner dependent on the p53 methylation site.


Gene Aliases:

FLJ21193; KIAA1717; KMT7; SET7; SET7/9; SET9


Genbank Number:


References:


1. Wang, H. et al: Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Molec. Cell 8: 1207-1217, 2001.

2. Chuikov, S. et al: Regulation of p53 activity through lysine methylation. Nature 432: 353-360, 2004.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~75 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology


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  Methyltransferase Dilution Buffer I, M21-09

  Histone H1 Protein, H10-54N


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