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EIF2AK1 (HRI), Active

Recombinant full-length human EIF2AK1 (HRI) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H07-10G


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Catalog No. Pack Size Price (USD)
H07-10G-10 10 ug $325
H07-10G-05 5 ug $226
H07-10G-BULK BULK Contact Us  


Overview:

EIF2AK1 (HRI) or eukaryotic translation initiation factor 2-alpha kinase 1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. EIF2AK1 (HRI) is a kinase that can be inactivated by hemin and is activated by heme deficiency and other stimuli and is a major protein kinase that phosphorylates EIF2-alpha (1). EIF2AK1 (HRI) is downregulated in the majority of ovarian cancers compared with normal ovarian tissues. EIF2AK1 (HRI) functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia (2).


Gene Alisases:

HCR; HRI; KIAA1369


Genbank Number:


References:


1. Hwang. et.al: Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2-alpha kinase: down-regulated in epithelial ovarian cancers. Molec. Cells 10: 584-591, 2000.

2. Liu, S. et.al: The function of heme-regulated elF2-alpha kinase in murine iron homeostasis and macrophage maturation. J. Clin. Invest. 117: 3296-3305, 2007.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~120 kDa



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cellular Stress, Inflammation, Neurobiology, Ser/Thr Kinases


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