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MLK3, Active

Recombinant human MLK3 (1-488) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M19-11G


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Catalog No. Pack Size Price (USD)
M19-11G-05 5 ug $226
M19-11G-10 10 ug $325
M19-11G-BULK BULK Contact Us  


Overview:

MLK3 or Mixed-Lineage Kinase 3 is a mitogen-activated protein kinase kinase kinase capable of preferentially activating MAPK8/JNK kinase and functions as a positive regulator of JNK signaling pathway (1). MLK3 can directly phosphorylate and activate IkappaB kinase α and β, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. MLK3 is a signal-integrating kinase with conventional MAP3K catalytic activity and additional noncatalytic functions that contribute to RAF/ERK signalling (2). MLK3 is a component of the BRAF/RAF1 complex and is required for integrity of the complex and for activation of ERK by the complex.


Gene Alisases:

MAP3K11, PTK1, SPRK, MLK3, MGC17114, MLK-3


Genbank Number:


References:


1. Ing, Y. L. et al: MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. Oncogene 9: 1745-1750, 1994.

2. Chadee, D. N. et al: MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nature Cell Biol. 6: 770-776,2004.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~83 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Apoptosis/Autophagy, Cell Cycle, JNK/SAPK Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  MLK2, Active, M18-11G

  GCK, Active, M24-10G

  HPK1, Active, M23-11G

  JNK1, Active, M33-10G


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