Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies
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Product Name Catalog Number Pack Size Price(USD)  
BMP-2 B851-40N-10 10 ug $204 Contact Us
BMP-2 B851-40N-50 50 ug $325 Contact Us
BMP-2 B851-40N-BULK BULK Contact Us  

Description: Human active form BMP-2 (283-396) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping : Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Cell Assay

Endotoxin Level : Less than 0.1 ng/ug (IEU/ug) of BMP-2.

Molecular Weight : ~13.8 kDa

Gene Aliases : BMP2A

Scientific Background : BMP-2 is a member of the bone morphogenetic protein family that is part of the transforming growth factor-beta (TGFB) superfamily. BMP-2 acts as a disulfide-linked homodimer that induces bone and cartilage formation. BMP2 modulates fibroblast-like synoviocyte cell populations in inflamed synovium (1). BMP2 plays a role in human T-cell differentiation and involve in the long bone formation (2).

References :
1. Lories, R. J. U. et.al: Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum. 48: 2807-2818, 2003.

2. Cejalvo, T. et.al: Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology 121: 94-104, 2007.

Product Sheets

Research Areas
AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, WNT Signaling,

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