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Anti-AKT3

Rabbit Polyclonal Antibody
Catalog No. A18-63R


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Catalog No. Pack Size Price (USD)
A18-63R-25 25 ug $127
A18-63R-100 100 ug $347
A18-63R-BULK BULK Contact Us  


Overview:

AKT 3 or Protein Kinase B (PKB ) is a serine/threonine kinase that is a member of the AKTγ (PKBγB family. AKT 3 is activated in cells exposed to diverse stimuli such as hormones, growth factors, and extracellular matrix components (1). AKT 3 phosphorylates and regulates the function of many cellular proteins involved in processes that include cellular metabolism, survival/apoptosis, and proliferation. Recent evidence indicates that AKT 3 is frequently overexpressed in many types of human cancers including breast and prostate (2).

References:


1. Coffer, PJ. et al: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998 Oct 1; 335 (Pt 1): 1-13.

2. Anderson, KE. et al: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol. 1998 Jun 4;8(12): 684-91.


Specificity:

Recognizes the AKT3 protein


Cross Reactivity:

Western blot AKT3 from human and mouse cells

AKT3 from other species may also be detectable.


Host:

Rabbit


Immunogen:

Protein Code: Q9Y243


Purification:

Affinity Chromatography


Stability:

Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.


Sample Data:

Representative western blot (1:1000) with Anti-AKT3 using 20 ng of human full length recombinant AKT1, AKT2, and AKT3.



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Inflammation, Neurobiology


RELATED PRODUCTS


  AKT3, Active, A18-10G

  Anti-Rabbit HRP, G33-62G

  Anti-AKT (pan), A16-63R

  Modified AKT Substrate, A05-58B


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