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HO2 Protein

Recombinant full-length human HO2 Protein was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. H21-30G


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Catalog No. Pack Size Price (USD)
H21-30G-50 50 ug $435
H21-30G-20 20 ug $215
H21-30G-BULK BULK Contact Us  


Overview:

HO2, or heme oxygenase 2, belongs to the heme oxygenase family that are essential enzyme in heme catabolism that cleave heme to form biliverdin which is subsequently converted to bilirubin by biliverdin reductase (1). HO2 is part of the calcium-sensitive potassium channel complex and enhances channel activity in normoxia (2). Knockdown of HO2 expression reduces channel activity, an effect that is reversed by carbon monoxide. Inhibition of calcium-sensitive potassium channels by hypoxia is dependent on HO2 expression and is augmented by HO2 stimulation.


Gene Alisases:

HMOX2


Genbank Number:


References:


1. Kemp, P.J. et al: Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction. Biochem Biophys Res Commun. 2005;338(1):648-52.

2. Williams, S. E. et al: Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science. 2004 Dec 17;306(5704):2093-7.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~62kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology


RELATED PRODUCTS


  HO1 Protein, H20-30G


SIGNALCHEM BIOTECH INC.


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