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NNMT (Dog), Active

Recombinant full-length Canis lupus NNMT was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N330D-380G


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Catalog No. Pack Size Price (USD)
N330D-380G-05 5 ug $259
N330D-380G-10 10 ug $380
N330D-380G-BULK BULK Contact Us  


Overview:

Nicotinamide N-methyltransferase (NNMT) is expressed predominantly in the liver, and mediates the N-methylation of nicotinamide and other pyridines. The activity of NNMT is involved in drug and xenobiotic toxicity (1). NNMT has also been identified as serum tumor marker for colorectal cancer (2), as well as potential marker in urine-based diagnostic test for bladder cancer (3).


Gene Aliases:

None


Genbank Number:


References:


1. Aksoy, S., et al. Human liver nicotinamide N-methyl-transferase. cDNA cloning, expression, and biochemical characterization. J Biol Chem. 269(20):14835-40, 1994.

2. Roessler, M., et al. Identification of nicotinamide N-methyl-transferase as a novel serum tumor marker for colorectal cancer. Clin Cancer Res. 11(18):6550-7, 2005.

3. Sartini, D., et al. Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: potential for the development of a urine-based diagnostic test. Cell Biochem Biophys. 65(3):473-83, 2013.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

54 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


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