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MUTANT KINASES - TRKA (G667S), Active (N16-12NG)

Product Name Catalog Number Pack Size Price(USD)  
TRKA (G667S), Active N16-12NG-05 5 ug $226 Add to Cart
TRKA (G667S), Active N16-12NG-10 10 ug $325 Add to Cart
TRKA (G667S), Active N16-12NG-BULK BULK Contact Us  


Description: Recombinant human TRKA (G667S) (440-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: 440-end (G667S)

Genbank Number: NM_002529    


Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability, and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Mutants

Molecular Weight : 66 kDa

Gene Aliases : NTRK1; MTC; TRK; TRK1; p140-TrkA; DKFZp781I14186

Scientific Background : TRKA is a member of the trk proto-oncogene family and encodes a 140kDa, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2).

References :
1. Kaplan, D R. et al: The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991 Apr 26;252(5005):554-8.

2. Boissiere, F. et al: Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):219-23.

Product Sheets

SDS

Research Areas
Neurobiology, Receptor Tyrosine Kinases,

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