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MUTANT KINASES - MET (L1195V), Active (M52-12TG)

Product Name Catalog Number Pack Size Price(USD)  
MET (L1195V), Active M52-12TG-05 5 ug $226 Add to Cart
MET (L1195V), Active M52-12TG-10 10 ug $325 Add to Cart
MET (L1195V), Active M52-12TG-BULK BULK Contact Us  


Description: Recombinant human MET (L1195V) (956-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: 956-end (L1195V)

Genbank Number: NM_000245    


Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability, and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay

Molecular Weight : 81 kDa

Gene Aliases : HGFR, RCCP2

Scientific Background : MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue (1). Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion (2).

References :
1. Giordano, S. et al: Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene. 1989 Nov;4(11):1383-8.

2. Iyer, A. et al: Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. Cell Growth Differ. 1990 Feb;1(2):87-95.

Product Sheets

SDS

Research Areas
Cancer, Receptor Tyrosine Kinases,

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