Home   >   Enzymes   >   Kinases

ERN1 (IRE1), Active

Recombinant mouse ERN1 (IRE1) (469-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E31M-11G

Shop Online

Catalog No. Pack Size Price (USD)
E31M-11G-05 5 ug $226
E31M-11G-10 10 ug $325
E31M-11G-BULK BULK Contact Us  


ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2).

Gene Alisases:

Ire1a; Ire1p; C85377; AI225830; Ire1alpha; 9030414B18Rik

Genbank Number:


1. Niwa, M. et.al: A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702, 1999.

2. Iwawaki, T. et.al: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Nat. Acad. Sci. 106: 16657-16662, 2009.

Specific Activity:

ample Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

87 kDa

Product Datasheets

Safety Datasheet

There are no related publications available for this product.


Angiogenesis, Cellular Stress, Neurobiology, Ser/Thr Kinases


  Kinase Dilution Buffer X, K20-09

  Kinase Assay Buffer III, K03-09

  MBP Protein, M42-51N

  Kinase Dilution Buffer IX, K29-09



Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox