Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies
| Shopping Cart EN/中文
Due to Good Friday holiday, all delivery service requests will not be processed on April 19, 2019. Regular delivery schedule will resume on April 22, 2019.
 

KINASES - ERN1 (IRE1), Active (E31M-11G)

Product Name Catalog Number Pack Size Price(USD)  
ERN1 (IRE1), Active E31M-11G-05 5 ug $226 Add to Cart
ERN1 (IRE1), Active E31M-11G-10 10 ug $325 Add to Cart
ERN1 (IRE1), Active E31M-11G-BULK BULK Contact Us  


Description: Recombinant mouse ERN1 (IRE1) (469-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species: Mouse

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: 469-end

Genbank Number: NM_023913    


Specific Activity : ample Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability, and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : 87 kDa

Gene Aliases : Ire1a; Ire1p; C85377; AI225830; Ire1alpha; 9030414B18Rik

Scientific Background : ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2).

References :
1. Niwa, M. et.al: A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702, 1999.

2. Iwawaki, T. et.al: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Nat. Acad. Sci. 106: 16657-16662, 2009.

Product Sheets

SDS

Research Areas
Angiogenesis, Cellular Stress, Neurobiology, Ser/Thr Kinases,

Related Products

  Terms of Service | Privacy Policy  
  @ 2018 SignalChem.All rights reserved