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UCHL5, Active

Recombinant full length human UCHL5, was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U526-380H


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Catalog No. Pack Size Price (USD)
U526-380H-05 5 ug $226
U526-380H-10 10 ug $325
U526-380H-BULK BULK Contact Us  


Overview:

UCHL5 (Ubiquitin carboxyl-terminal hydrolase isozyme L5) is a member of the peptidase C12 family of deubiquitinating enzymes and specially cleaves 'Lys-48'-linked polyubiquitin chains. UCHL5 is associated with the 19S regulatory subunit of the 26S proteasome and may play a role as a putative regulatory component of the INO80 complex (1). High expression of UCHL5 has also been indicated to be correlated with increased disease-specific survival in lymph-node-positive rectal cancer, suggesting that it could be a possible novel prognostic marker (2).


Gene Alisases:

UCH-L5, UCH37, CGI-70, INO80R


Genbank Number:


References:


1. Yao, T.T. et al: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Molecular cell 31(6): 909-17, 2008.

2. Arpalahti, L. et al: UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer. Tumor Biology: 1-8, 2017.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

38 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


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