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IRAK1, Active

Recombinant full-length human IRAK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I09-10G


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Catalog No. Pack Size Price (USD)
I09-10G-05 5 ug $259
I09-10G-10 10 ug $380
I09-10G-BULK BULK Contact Us  


Overview:

IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. The exposure of HeLa cells or human embryonic kidney cells overexpressing IL1R to IL1 caused rapid association of IRAK with the IL1R complex and phosphorylation of IRAK (1). IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus (2).


Gene Alisases:

IRAK, Pelle


Genbank Number:


References:


1. Cao, Z.et.al: IRAK: a kinase associated with the interleukin-1 receptor. Science 271: 1128-1131, 1996.

2. Jacob, C. O. et.al: Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc. Nat. Acad. Sci. 106: 6256-6261, 2009.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

132 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases


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