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Tau-412 Protein

Recombinant full-length human tag-free Tau-412 was expressed in E. coli cells.
Catalog No. T07-54N


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Catalog No. Pack Size Price (USD)
T07-54N-50 50 ug $336
T07-54N-20 20 ug $160
T07-54N-BULK BULK Contact Us  


Overview:

Tau-412 or Tau-E is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).


Gene Alisases:

Tau-E, (N1R4), MAPT, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549


Genbank Number:


References:


1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.

2. Rial, A. et al: Calcium Dyshomeostasis in β-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Tau Proteins:

Representation of seven Tau proteins, from top to bottom: Tau-441, Tau-410, Tau-412, Tau-381, Tau-383, Tau-352 and Tau-316 (Tau Protein Marker; Cat # T08-07N).


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~58 kDa



RESEARCH AREAS

Invasion/Metastasis, Neurobiology, p38 Pathway


RELATED PRODUCTS


  ERK1, Active, M29-10U

  CDK2/CyclinA2, Active, C29-10G

  Tau-441, BRSK2-phosphorylated, T08-50BN

  Tau-441, DYRK1A-phosphorylated, T08-50RN


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