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SAE1/UBA2 Complex, Active

Recombinant full-length human SAE1 (UBLE1A) and human UBA2 (SAE2) were co-expressed by baculovirus in Sf9 insect cells.
Catalog No. U208-380G


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Catalog No. Pack Size Price (USD)
U208-380G-20 20 ug $215
U208-380G-50 50 ug $435
U208-380G-BULK BULK Contact Us  


Overview:

SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins to regulate protein structures and intracellular localization (1). The SAE1/SAE2 dimer functions in SUMO1 activation in a manner analogous to the single E1 ubiquitin-activating enzymes (2). The SAE2 inactivation may be a therapeutic strategy in MYC-driven cancers (3).


Gene Aliases:

SAE1: UBLE1A; SUA1; HSPC140; AOS1; FLJ3091
UBA2: SAE2; UBLE1B; SAE2; ARX; HRIHFB2115


Genbank Number:


References:


1. Okuma, T. et.al: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254: 693-698, 1999.

2. Desterro, J. et. al: Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J. Biol. Chem. 274: 10618-10624, 1999.

3. Kessler, J. D. et.al: A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science 335: 348-353, 2012.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

SAE1 ~39 kDa and UBA2 ~115 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Neurobiology


RELATED PRODUCTS


  SUMO2 Protein, S294-31H

  UBE2I (UBC9), Active, U224-380H

  RanBP2, Active, R230-381H


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