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Indirubin-3’-monoxime

GSK-3b / CDK kinase inhibitor
Catalog No. C29-901


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Catalog No. Pack Size Price (USD)
C29-901-05 5 mg $83
C29-901-25 25 mg $303
C29-901-BULK BULK Contact Us  


Overview:

A potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells2.

References:


1. S Leclerc et al. J. Biol. Chem. 2001 276:251

2. E Damiens et al. Oncogene 2001 20:3786

3. JK Kim et al. J. Cell. Biochem. 2011 112:1384

4. Y Ding et al. Neurobiol. Dis. 2010 39:156


CAS Registry Number:

160807-49-8


Molecular Formula:

C16H11N3O2


Appearance:

Dark red to brown powder


Molecular Weight:

277.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (6 mg/ml) or ethanol (4 mg/ml, warm)


Aliases:

Indirubin-3’-oxime 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one


Storage and Stability:

Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



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