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LYN A, Active

Recombinant full-length human LYN A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. L13-18G


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Catalog No. Pack Size Price (USD)
L13-18G-05 5 ug $226
L13-18G-10 10 ug $325
L13-18G-BULK BULK Contact Us  


Overview:

LYN A is a member of the Src-family of protein kinases that participate in signaling pathways of a variety of cell surface receptors and are localized to the cytoplasmic side of the plasma membrane (1). LYN A is biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway. The trafficking of LYN A from the Golgi apparatus to the plasma membrane is inhibited by deletion of the kinase domain but not by kinase inactivation. The kinase domain of LYN A plays a role in LYN A trafficking besides catalysis of substrate phosphorylation. cDNA microarray analysis revealed that LYN A may be involved in the changes that are related to tumor pathogenesis (2).


Gene Alisases:

JTK8, FLJ26625


Genbank Number:


References:


1. Kasahara, K. et al: Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain. J. Cell Biol., 2004;165(5):641-52.

2. Baran, C.P. et al: The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony stimulating factor-induced Akt activity. J. Biol. Chem. 2003; 278(40):38628-36


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~81 kDa



RESEARCH AREAS

AKT/PKB Pathway, Cancer, Cardiovascular Disease, Cellular Stress, Cytoplasmic Tyrosine Kinases, Inflammation


RELATED PRODUCTS


  FGR, Active, F10-10G

  SRC, Active, S19-10G

  ABL1, Active, A03-18H

  FYN A, Active, F15-10G


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