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KINASES - RIPK1, Active (R07M-11G)

Product Name Catalog Number Pack Size Price(USD)  
RIPK1, Active R07M-11G-05 5 ug $435 Add to Cart
RIPK1, Active R07M-11G-10 10 ug $655 Add to Cart
RIPK1, Active R07M-11G-BULK BULK Contact Us  


Description: Recombinant mouse RIPK1 (1-327) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species: Mouse

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: 1-327

Genbank Number: NM_009068    


Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability, and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~62 kDa

Gene Aliases : D330015H01Rik; Rinp; RIP; Rip1

Scientific Background : RIPK1 or Receptor Interacting Protein Kinase 1 is a serine/threonine kinase that was originally identified as interacting with the cytoplasmic domain of FAS. RIPK1 has been deemed as an important element in the signal transduction machinery that mediates programmed cell death. RIPK1 has been shown to interact with TRADD, TRAF1 TRAF2 and TRAF3 and TRADD can act as an adaptor protein to recruit RIPK1 to the TNFR1 complex in a TNF-dependent process (1). TNFα is capable of activating the noncanonical NF-κB pathway, but this activation of this pathway is negatively regulated by RIPK1 (2).

References :
1. Hsu, H. et al: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387-396, 1996.

2. Kim, J Y. et al: TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2. J Cell Sci. 2011 Feb 15;124(Pt 4):647-56.


Product Sheets

SDS

Research Areas
Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, p38 Pathway, Ser/Thr Kinases,

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