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METTL3/METTL14, Active

Full-length recombinant human METTL3/METTL14 complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M323-380G


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Catalog No. Pack Size Price (USD)
M323-380G-05 5 ug $259
M323-380G-10 10 ug $380
M323-380G-BULK BULK Contact Us  


Overview:

Methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) form a stable heterodimer core complex that catalyzes N6-methyladenosine (m6A) RNA methylation in mammalian cells. m6A is an abundant internal modification in messenger RNA and long non-coding RNA. It functions in multiple aspects of developmental regulation, cell cycle progression, cell fate, and the heat shock stress response by affecting aspects of RNA metabolism such as pre-mRNA processing, translation efficiency, transcript stability and miRNA biogenesis.


Gene Aliases:

METTL3: IME4; M6A; MT-A70; Spo8
METTL14: None


Genbank Number:


References:


1. Liu J. et al: A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 2014; 10: 93–95

2. Wang X. et al: Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex. Nature 2016; 534:575-578

3. Wang P. et al: Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol. Cell 2016; 63(2):306-317


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

100 kDa (METTL3) and 84 kDa (METTL14)



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Neurobiology


RELATED PRODUCTS


  METTL3/METTL14 Substrate, M323-58

  DTT Solution, D86-09B


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