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Ubiquitin Protein

Recombinant human tag free ubiquitin (1-76) protein was expressed in E. coli cells.
Catalog No. U06-54N


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Catalog No. Pack Size Price (USD)
U06-54N-200 200 ug $105
U06-54N-500 500 ug $160
U06-54N-BULK BULK Contact Us  


Overview:

Ubiquitin is a highly-conserved protein that is widely expressed in eukaryotes (1). Ubiquitin is required for the rapid proteasomal degradation of intracellular proteins in an ATP-dependent manner. UBB+1 is a frameshift mutant form of ubiquitin, which not only inhibits the function of the proteasome machinery, but also accumulates in the cells associated with tauopathies, including Alzheimer's disease and polyglutamine diseases because of the cell’s inability to clear cytotoxic misfolded amyloid-beta and phosphorylated-tau (2). UBB+1 also serves as an endogenous marker for proteasomal dysfunction in liver disease and muscle disease, where the protein may also have a role in pathogenesis.


Gene Aliases:

UBB, MGC8385, FLJ25987


Genbank Number:


References:


1. Baker, R T. et al: The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. Nucleic Acids Res.15: 443-463, 1987.

2. Fratta, P. et al: Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. Neurology. 2004 Sep 28;63(6):1114-7.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

10 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Inflammation, Invasion/Metastasis, Neurobiology


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