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CELL STRESS & CHAPERONE PROTEINS - 14-3-3 zeta Protein (Y92-30H)

Product Name Catalog Number Pack Size Price(USD)  
14-3-3 zeta Protein Y92-30H-20 20 ug $314 Add to Cart
14-3-3 zeta Protein Y92-30H-50 50 ug $545 Add to Cart
14-3-3 zeta Protein Y92-30H-BULK BULK Contact Us  


Description: Recombinant full-length human 14-3-3 zeta was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Species: Human

Tag: His tag

Expression System: Sf9 insect cells using baculovirus

Sequence: Full length

Genbank Number: NM_003406    


Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability, and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : 31 kDa

Gene Aliases : 14-3-3 zeta, YWHAZ, KCIP-1, MGC111427, MGC126532, MGC138156

Scientific Background : 14-3-3 zeta (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 zeta protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3 zeta protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2).

References :
1. Li, Z. et al: Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proc Natl Acad Sci U S A. 2008; 105(1):162-7.

2. Niemantsverdriet, M. et al: Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character. Oncogene. 2008;27(9):1315-9. 2007.

Product Sheets

Research Areas
AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, WNT Signaling,

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