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WHSC1 (NSD2), Active

Recombinant human WHSC1 (911-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N377-381G


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Catalog No. Pack Size Price (USD)
N377-381G-05 5 ug $259
N377-381G-10 10 ug $380
N377-381G-BULK BULK Contact Us  


Overview:

Histone-lysine N-methyltransferase NSD2 or Multiple myeloma SET domain-containing protein (MMSET) is a histone methyltransferase (HMT) with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Overexpressed in t(4;14)+ multiple myeloma (MM) patients, leading to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in histone 3 lysine 27 trimethylation (H3K27me3), accompanied by changes in proliferation, gene expression and chromatin accessibility.


Gene Aliases:

MMSET; WHSC1; REIIBP; TRX5; WHS


Genbank Number:


References:


1. Shah MY, et al: MMSET/WHSC1enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.116.

2. Morishita M, et al: Cancers and the NSD family of histone lysine methyltransferases. Biochim Biophys Acta. 2011 Dec;1816(2):158-63.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

80 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, NfkB Pathway



SIGNALCHEM BIOTECH INC.


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