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SETD6, Active

Recombinant full-length human SETD6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S355-380G


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Catalog No. Pack Size Price (USD)
S355-380G-05 5 ug $259
S355-380G-10 10 ug $380
S355-380G-BULK BULK Contact Us  


Overview:

SET domain-containing protein 6 (SETD6) is a mono-methyltransferase that has been shown to methylate RelA of NF-kappa-B complex and thus attenuate NF-kappa-B transcription factor activity. In addition, it monomethylates the histone H2A variant H2AZ which is required for the maintenance of embryonic stem cell self-renewal.


Gene Aliases:

None


Genbank Number:


References:


1. Levy D, et al: Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyl-transferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol. 2011 12(1):29-36.

2. Binda O, et al: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics. 2013 8(2):177-83.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

75 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



SIGNALCHEM BIOTECH INC.


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