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SETD2 (KMT3A), Active

Recombinant human SETD2 (1425-1717) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S343-381G


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Catalog No. Pack Size Price (USD)
S343-381G-05 5 ug $259
S343-381G-10 10 ug $380
S343-381G-BULK BULK Contact Us  


Overview:

As a member of the mixed lineage leukemia (MLL) family of histone methyltransferase, SETD2 specifically tri-methylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. The main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation.


Gene Aliases:

KMT3A; HBP231; HIF-1; HIP-1; HSPC069; HYPB; p231HBP; SET2


Genbank Number:


References:


1. Li Y, et al: Structural basis for activity regulation of MLL family methyltransferases. Nature. 530(7591):447-52. 2016

2. http://www.uniprot.org/uniprot/Q9BYW2


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

61 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



SIGNALCHEM BIOTECH INC.


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