Phenylethanolamine N-methyltransferase (PNMT) catalyzes the biosynthesis of adrenaline though methylation of phenylethanolamine (1). PNMT gene is reported to be involved in various human diseases including early-onset Alzheimer disease (2), Parkinson's disease (3), and multiple sclerosis (4). Expression of PNMT can be stimulated by nicotine (5).
1. Kaneda, N., et al. Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis. J Biol Chem. 263(16):7672-7, 1988.
2. Mann, M.B., et al. Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease. Am J Med Genet. 105(4):312-6, 2001.
3. Gearhart, D.A., et al. Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease. Neurochem Int. 40(7):611-20, 2002.
4. Mann, M.B., et al. Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis. J Neuroimmunol. 124(1-2):101-5, 2002.
5. Evinger, M.J., et al. Nicotine stimulates expression of the PNMT gene through a novel promoter sequence. J Mol Neurosci. 26(1):39-55, 2005.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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