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MLL3 (KMT2C), Active

Recombinant human MLL3 (4689-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M343-381G


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Catalog No. Pack Size Price (USD)
M343-381G-05 5 ug $259
M343-381G-10 10 ug $380
M343-381G-BULK BULK Contact Us  


Overview:

Histone-lysine N-methyltransferase 2C, also known as mixed-lineage leukemia 2 (MLL3) is the central component of the MLL2/3 complex, a coactivator complex of nuclear receptors involved in transcriptional coactivation. Deletion of the region harboring the MLL3 gene was found to be the most frequently recurrent chromosomal abnormality in acute myeloid leukemia.


Gene Aliases:

MLL3; KMT2C; HALR


Genbank Number:


References:


1. Rao RC, et al: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 15(6): 334-46. 2015.

2. Ford DJ, et al: The cancer COMPASS: navigating the functions of MLL complexes in cancer. Cancer Genet. 208(5):178-91. 2015

3. http://www.uniprot.org/uniprot/Q8NEZ4


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

51 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer



SIGNALCHEM BIOTECH INC.


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